在α-synucleinopathies的神经精神症状的性别差异:一个系统的审查和元分析
Vincent Couture1, Jean-François Carmel2, Katerine Rousseau1
1Department of Psychiatry, Division of Geriatric Psychiatry, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada.
Movement disorders clinical practice
|October 10, 2024
概括
神经精神症状 (NPS) 在性别之间的α-synucleinopathies中表现不同. 这一元分析揭示了基于性别的帕金森病 (PD),勒维体痴呆症 (DLB) 和帕金森病痴呆症 (PDD) 的明显NPS患病率和严重程度.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 包括帕金森病 (PD),勒维体痴呆症 (DLB) 和帕金森病痴呆症 (PDD) 在内的α-synucleinopathies在疾病进展和呈现方面表现出已知的基于性别的变化.
- 神经精神症状 (NPS) 是这些神经退行性疾病的早期和晚期显著表现.
研究的目的:
- 在各种α-synucleinopathies中调查和描述NPS流行率和严重性的特定性别差异.
- 为了提供一个全面的概述,NPS如何在这个神经退行性疾病群体中的男性和女性中表现得不同.
主要方法:
- 在2000年1月1日至2022年6月1日期间发表的观测研究的Web of Science核心集合数据库上进行了系统的文献搜索.
- 包括报告在被诊断为PD,PDD或DLB的个体中NPS患病率或严重程度的研究.
- 采用随机效应模型,将每个NPS的患病率和严重性数据汇集起来,按性别分层.
主要成果:
- 分析包括240项研究,其中796,026名参与者 (45%为女性).
- 女性性别与焦虑,抑郁和疲劳的患病率和严重程度的增加,以及精神病症状的更高患病率有关.
- 男性的性别与较高的冷漠,冲动控制障碍,REM睡眠行为障碍,超眠症和自杀的患病率有关.
结论:
- 在α-synucleinopathies中,神经精神病症状在男性和女性之间存在明显的流行和严重程度模式.
- 这些性别特异性差异强调了将性别视为发展和完善这些疾病的临床诊断和管理工具的关键因素的重要性.
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