比较毒基因组学数据库20周年:更新至2025年
Allan Peter Davis1, Thomas C Wiegers1, Daniela Sciaky1
1Department of Biological Sciences, 3510 Thomas Hall, 112 Derieux Place, North Carolina State University, Raleigh, NC 27695, USA.
Nucleic acids research
|October 10, 2024
概括
在过去的20年里,比较毒基因组学数据库 (CTD) 显著增长,现在已经将环境化学物质和人类健康之间的9400多万个联系联系起来. 此更新突出了新的功能和数据内容,以帮助环境健康研究.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物信息学是一种生物信息学.
背景情况:
- 比较毒基因组学数据库 (CTD) 提供了二十年来基于文献的毒基因组数据.
- CTD将化学物质与基因,蛋白质,表型,疾病和暴露联系起来,支持环境健康研究.
- 数据库在数据内容和功能方面经历了大幅增长.
研究的目的:
- 为了纪念CTD20周年,反思其成长.
- 提供CTD扩展数据内容和新功能的概述.
- 突出策划,工具和基础设施方面的改进.
主要方法:
- 基于文献的毒基因组学信息的策划.
- 集成受控词汇来链接实验室和暴露数据.
- 改善策划工作流程,包括自然语言处理和新工具.
- 软件和基础设施的升级,以提高功能.
主要成果:
- 现在CTD包含超过9400万个毒基因组连接.
- 新功能包括一个曝光修复工具,改进的CTD Tetramers和Pathway View.
- 在整个环境健康连续过程中加强策划和基础设施支持分析.
结论:
- CTD已经从一个原型演变为环境健康发现的首要知识库.
- 该数据库为研究化学物质对人类健康影响的科学家提供了假设生成的便利.
- 持续的开发提高了CTD的实用性,以了解环境暴露的分子到人口层面的影响.
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