Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Genomics02:02

Genomics

36.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Linking chemical data from the Comparative Toxicogenomics Database with adverse outcome pathways from the AOP-Wiki: a mechanistic data-oriented approach to help inform environmental health.

F1000Research·2026
Same author

Comparative effectiveness of cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular outcomes: A comprehensive Bayesian network meta-analysis and network meta-regression.

Medicine·2026
Same author

Unraveling the Complexities of Kartagener's Syndrome: A Case of Bronchiectasis, Isolated Dextrocardia, and Primary Ciliary Dyskinesia in an Adult With Chronic Respiratory Symptoms.

Clinical case reports·2026
Same author

Epidemiologic trajectories and burden of multidrug-resistant tuberculosis (MDR-TB) mortality across South Asia: An analysis of Global Burden of Disease data (1990-2023) with machine learning forecasting to 2050.

Journal of clinical tuberculosis and other mycobacterial diseases·2026
Same author

Cerebral Abscess Masquerading as Tuberculoma in a Post-Renal Transplant Chronic Kidney Disease Patient: A Diagnostic and Therapeutic Challenge.

Clinical case reports·2026
Same author

Navigating the HIV/AIDS epidemic in Bangladesh: A comprehensive retrospective analysis of epidemiological trends and sex-specific disparities (1990-2021) with long-term ARIMA forecasting to 2050 for strategic public health planning.

Journal of virus eradication·2026

相关实验视频

Updated: Jun 11, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.1K

比较毒基因组学数据库20周年:更新至2025年

Allan Peter Davis1, Thomas C Wiegers1, Daniela Sciaky1

  • 1Department of Biological Sciences, 3510 Thomas Hall, 112 Derieux Place, North Carolina State University, Raleigh, NC 27695, USA.

Nucleic acids research
|October 10, 2024
PubMed
概括
此摘要是机器生成的。

在过去的20年里,比较毒基因组学数据库 (CTD) 显著增长,现在已经将环境化学物质和人类健康之间的9400多万个联系联系起来. 此更新突出了新的功能和数据内容,以帮助环境健康研究.

更多相关视频

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.6K
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.6K

相关实验视频

Last Updated: Jun 11, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.1K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.6K
Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.6K

科学领域:

  • 环境健康 环境健康
  • 毒理学 毒理学 毒理学
  • 生物信息学是一种生物信息学.

背景情况:

  • 比较毒基因组学数据库 (CTD) 提供了二十年来基于文献的毒基因组数据.
  • CTD将化学物质与基因,蛋白质,表型,疾病和暴露联系起来,支持环境健康研究.
  • 数据库在数据内容和功能方面经历了大幅增长.

研究的目的:

  • 为了纪念CTD20周年,反思其成长.
  • 提供CTD扩展数据内容和新功能的概述.
  • 突出策划,工具和基础设施方面的改进.

主要方法:

  • 基于文献的毒基因组学信息的策划.
  • 集成受控词汇来链接实验室和暴露数据.
  • 改善策划工作流程,包括自然语言处理和新工具.
  • 软件和基础设施的升级,以提高功能.

主要成果:

  • 现在CTD包含超过9400万个毒基因组连接.
  • 新功能包括一个曝光修复工具,改进的CTD Tetramers和Pathway View.
  • 在整个环境健康连续过程中加强策划和基础设施支持分析.

结论:

  • CTD已经从一个原型演变为环境健康发现的首要知识库.
  • 该数据库为研究化学物质对人类健康影响的科学家提供了假设生成的便利.
  • 持续的开发提高了CTD的实用性,以了解环境暴露的分子到人口层面的影响.