在温和温度下精确的光热疗法:NIR-II成像导向,H2O2-响应式隐形纳米炸弹
Gongcheng Ma1, Qihang Ding2, Yue Wang3
1School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003, P. R. China.
Advanced healthcare materials
|October 10, 2024
概括
一种新的隐形纳米炸弹 (SNB) 有效地抑制癌细胞中的热冲击蛋白. 这提高了温和温度光热疗法 (PTT) 的有效性,并降低了全身毒性,改善了癌症治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 温和温度光热疗法 (PTT) 的有效性受到癌细胞激活热冲击蛋白 (HSP) 的限制.
- 之前的纳米炸弹 (nanobomb1G) 抑制了HSP,但需要内注射.
- 需要改进的纳米载体来增强PTT.
研究的目的:
- 开发一种新的纳米炸弹 (隐形纳米炸弹,SNB) 用于静脉注射.
- 通过抑制HSPs来增强温和温度PTT的治疗疗效.
- 创建一个更安全,更有效的一氧化碳 (CO) 和治疗剂的联合交付系统.
主要方法:
- 具有CO载体聚合物 (PLGA(CO)) 和PEG脂质涂层的小分子NIR-II AIEgens的自组装.
- 静脉注射SNBs用于全身循环和瘤向.
- 在临床前模型中评估CO释放,HSP抑制和PTT疗效.
主要成果:
- SNBs使得安全的静脉注射和选择性瘤积累成为可能.
- 通过CO释放,SNBs有效地抑制了瘤细胞中的HSP表达.
- 与nanobomb1G相比,观察到温和温度PTT的治疗效率提高,系统毒性降低.
结论:
- 开发的隐形纳米炸弹 (SNB) 是PTT的一个重大进步.
- 国家银行为二氧化碳气体/药物联合交付提供了一个更安全,更稳定和更有效的平台.
- 这一策略有望改善抗瘤疗法,并尽量减少副作用.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
06:42Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
Published on: May 9, 2025
193
相关概念视频
01:29Methods of Sterilization I: Physical Methods
As used in a healthcare facility, sterilization destroys all microorganisms through physical or chemical methods. The physical method includes steam, dry heat, boiling water, and radiation.
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
Steam sterilization uses non-toxic, low-cost moist heat in the form of saturated steam under pressure, which is fast, microbicidal, and sporicidal, and quickly warms and penetrates fabrics. Autoclaves, or steam sterilizers, expose each item to direct steam contact for a predetermined time at the necessary...
01:23Physical Methods for Controlling Microbial Growth: Temperature
Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...