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Updated: Aug 11, 2026

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
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在肌性侧面硬化症中对皮层内部神经元电路的直接询问

Mehdi A J van den Bos1,2, Parvathi Menon1,2, Nathan Pavey1,2

  • 1Brain and Nerve Research Centre, Concord Clinical School, The University of Sydney, Sydney, NSW 2139, Australia.

Brain : a journal of neurology
|October 10, 2024
PubMed
概括

肌缩侧面硬化症 (ALS) 涉及由于GABAergic功能障碍而导致皮质过度兴奋. 新的TMS-EEG方法揭示了ALS患者的局部运动皮质GABAergic电路缺陷,与疾病严重程度相关.

关键词:
这是一种GABAergic内部神经元.骨髓缩侧面硬化症 (ALS) 是一种皮层过度刺激性 皮层过度刺激性短时间内皮层内抑制.通过皮唤起潜在的潜力.

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