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一个比较性研究的半球间的功能连接在患者的基底腺缺血性中风

Jian Zhang¹, Shijian Chen², Chengmin Yang³

¹Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Frontiers in aging neuroscience

|October 10, 2024

概括

沃克塞尔镜像同位素连接 (VMHC) 分析显示,在基底质缺血性中风 (BGIS) 患者中,半球间协调减少. 这种功能性大脑重塑可能解释单边中风后的运动缺陷.

科学领域:

神经成像是一种神经成像.
功能连接的功能连接性
脑卒中研究脑卒中研究

背景情况:

沃克塞尔镜像同位素连接 (VMHC) 评估了半球间的功能同步.
有限的研究存在于VMHC在基底腺缺血性中风 (BGIS) 跨半球.
这项研究使用静止状态功能性MRI (rs-fMRI) 调查了BGIS中的VMHC.

研究的目的:

评估左侧或右侧BGIS患者的VMHC变化.
在BGIS中建立了解半球功能连接的基线.
探索VMHC和临床结果之间的相关性.

主要方法:

招募了38个左侧BGIS,44个右侧BGIS和41个健康对照 (HC).
获取和预处理的rs-fMRI数据.
分析了VMHC,使用ANOVA和post hoc测试对比组;与临床尺度相关联.

主要成果:

与HC相比,LBGIS和RBGIS两组在后中心和前中心环节中显示了VMHC的减少.
在LBGIS和RBGIS组之间没有发现显著的VMHC差异.
在LBGIS中,减少的VMHC与NIHSS负相关,与BI分数正相关.

结论:

单边BGIS诱导大脑功能重塑与降低半球间同步.
观察到的VMHC变化可能是中风后运动功能障碍的基础.
VMHC 分析提供了对 BGIS 神经系统机制的见解.

关键词:

基底腺节缺血性中风脑卒中功能连接性的功能连接性静止状态的功能磁共振成像技术一次性中风中风中风中风中风沃克塞尔镜像同位体连接 voxel-mirrored 同位体连接

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