儿科食物过敏中的肠道微生物特征:范围审查
Margherita Farnetano1, Laura Carucci1,2, Serena Coppola1,2
1Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Frontiers in allergy
|October 10, 2024
概括
肠道微生物组 (GM) 的变化与儿科食品过敏 (FA) 有关. 这项审查发现,患有FA的儿童中有害细菌增加,有益细菌减少,这表明转基因作为治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 儿童食物过敏 (FA) 是一个越来越令人担忧的问题.
- 肠道微生物组 (GM) 越来越多地参与FA的发展.
- 了解转基因的作用对于儿科健康至关重要.
研究的目的:
- 审查当前关于小儿食物过敏的肠道微生物组变化的证据.
- 突出GM作为FA预防和治疗的潜在目标.
- 探索影响生命早期转基因生物的机制和环境因素.
主要方法:
- 根据PRISMA指南进行范围审查.
- 在PubMed和Embase数据库中进行了搜索.
- 包括34项研究,比较了患有FA和没有FA的儿童的转基因.
主要成果:
- 儿科FA与有害微生物 (例如,Enterobacteriaceae) 的增加有关.
- 有益的细菌 (例如Bifidobacteriaceae,Lactobacillaceae) 在儿科FA中较少.
- 特定的细菌物种和环境因素会影响免疫耐受性.
结论:
- 肠道微生物组的改变是儿科食物过敏病原体的核心.
- 针对转基因提供了新的诊断和治疗策略的潜力.
- 进一步的研究可以促进儿童的FA管理.
相关概念视频
Anatomy of the Intestines
71.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.5K
Bacterial Flora of the Large Intestine
394
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
394
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323


