慢性心力衰竭患者的门诊循环利尿剂减少模式的预后影响
Toshiharu Koike1, Atsushi Suzuki1, Noriko Kikuchi1
1Department of Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
International journal of cardiology. Heart & vasculature
|October 10, 2024
概括
降低心力衰竭患者的口服循环利尿剂量与更好的结果有关. 这项研究发现,剂量减少,特别是连续减少,显著降低死亡和住院的风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 在心力衰竭 (HF) 患者的门诊口服循环利尿剂 (LD) 剂量减少的预后影响尚不清楚.
- 现有的研究还没有明确定义LD剂量修改模式与患者结果之间的关系.
研究的目的:
- 调查门诊口服循环利尿剂 (LD) 剂量减少和心力衰竭 (HF) 患者的预后之间的不同模式之间的关联.
- 为了确定LD剂量减少是否可以作为HF管理中的预后指标.
主要方法:
- 分析了2015年9月至2019年8月期间的679名HF患者的LD队列.
- 根据随访期间的LD剂量变化,患者被分为无减少,单次减少和连续减少组.
- 主要结局包括全因死亡,高血压住院 (HFH) 和心血管死亡 (CVD) 或高血压死亡的复合.
主要成果:
- 在53.7个月的中位数随访期间,发生了156例死亡.
- 与没有减量组相比,LD剂量减量组显示出所有原因死亡的风险 (HR=0.65) 和心血管疾病或高血压的复合风险 (HR=0.69) 显著降低.
- 与单次减肥组相比,连续减肥组的CVD或HFH (HR=0.26) 和HFH (HR=0.34) 复合风险明显较低.
结论:
- 门诊口服循环利尿剂量减少的模式与心力衰竭患者的预后有关.
- 降低LD剂量,特别是连续降低,可以作为HF管理中有利预后的有价值指标.
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