肠道微生物群和胰岛素样生长因子之间的因果关系1:双向的双样本孟德尔随机化研究
Xuejie Zheng1, Yuping Qian2, Lili Wang1
1Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Frontiers in cellular and infection microbiology
|October 10, 2024
概括
这项研究揭示了肠道细菌与男性和女性的胰岛素样生长因子1 (IGF-1) 之间的双向因果关系,使用孟德尔随机分析.
科学领域:
- 微生物组研究的研究.
- 内分泌学 在内分泌学.
- 人类遗传学 人类遗传学
背景情况:
- 肠道微生物群和胰岛素样生长因子1 (IGF-1) 之间的相互作用尚未得到充分理解.
- 研究这种关系对于理解新陈代谢和生长调节至关重要.
研究的目的:
- 探索肠道微生物群组成和男性和女性IGF-1水平之间的双向因果关系.
- 确定影响IGF-1的特定细菌种群,反之亦然.
主要方法:
- 利用来自大型全基因组关联研究 (GWAS) 的单核酸多态 (SNPs) 的门德尔随机化 (MR) 分析.
- 采用逆方差加权 (IVW) 方法,并对异质性和性进行敏感性分析.
- 来自MiBioGen联盟的肠道微生物群数据和来自单独GWAS的IGF-1数据.
主要成果:
- 前期MR分析发现11种细菌种类对男性和14种女性因果影响IGF-1 (P <0.05),尽管在FDR校正后并不显著.
- 反向MR分析显示,IGF-1对男性的9种细菌种群和女性的2种细菌种群产生了因果影响 (P < 0.05).
- 在FDR后进行校正后,IGF-1对Actinomycetales顺序的因果作用在男性中仍然显著 (P = 0.049).
结论:
- 确定了两性肠道微生物群和IGF-1之间的双向因果关系.
- 表明肠道微生物组和IGF-1轴之间影响人类健康的复杂相互作用.
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