了解细胞动力学,工程视角和翻译前景在生物打印上皮质组织的前景
Irem Deniz Derman1,2, Joseph Christakiran Moses1,2, Taino Rivera3
1Engineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Bioactive materials
|October 10, 2024
概括
生物打印可以在体外产生功能性,偏振的上皮组织. 这项技术为研究疾病和推进个性化医疗保健提供了新的模型.
科学领域:
- 组织工程是组织工程.
- 生物技术是生物技术.
- 细胞生物学 细胞生物学
背景情况:
- 表皮组织形成关键的屏障,并在大多数器官中执行分泌功能.
- 在体外 (in vitro) 工程功能性表皮是具有挑战性的,因为其复杂的结构和细胞极性.
- 生物打印为制造两极化上皮组织提供了一种新的方法.
研究的目的:
- 通过生物打印来审查上皮组织及其工程.
- 为回顾表皮层的排列和极性提供洞察力.
- 讨论生物打印表皮的潜力作为体外模型.
主要方法:
- 对用于上皮质组织工程的生物打印技术现有文献的审查.
- 在实验室中分析实现基极和平面极性的方法.
- 讨论使用3D生物打印工程表皮的临床前研究.
主要成果:
- 生物打印技术已经在工程极化表皮上取得了成功.
- 生物打印组织可以作为体外模型用于恒温和疾病研究.
- 已经研究了研究3D生物打印工程表皮的各种方法.
结论:
- 生物打印是一种改造性技术,用于工程功能,极化上皮组织.
- 3D生物打印表皮对体外疾病建模和药物查充满希望.
- 为了将3D生物打印的上皮组织转化为个性化医疗保健,需要进一步的进展.
相关概念视频
Cell Migration
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Mechanical Protein Functions
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...


