病例报告:在一只猫中,扩散性大B细胞淋巴瘤呈现为充血性心力衰竭
Jake Johnson1, Hannah Melhorn1, Sonya Karchemskiy1
1Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, United States.
Frontiers in veterinary science
|October 10, 2024
概括
心脏淋巴瘤是一种罕见的引起猫的充血性心力衰竭的原因. 这种病例突出显示了一只患有猫免疫缺陷病毒的猫患有扩散性大B细胞淋巴瘤,这表明可能与疾病进展有关.
科学领域:
- 兽医病理学 兽医病理学
- 心脏病学 心脏病学
- 在瘤学瘤学.
背景情况:
- 心脏淋巴瘤是猫科动物不常见的疾病.
- 充血性心力衰竭 (CHF) 是一个常见的后果,但心脏淋巴瘤很少是主要考虑因素.
- 猫类免疫缺陷病毒 (FIV) 是猫中常见的一种逆转录病毒感染.
研究的目的:
- 报告一例罕见的猫患心脏扩散型大B细胞淋巴瘤.
- 讨论猫类伦氏病毒感染在心脏淋巴瘤病变发生中的潜在作用.
- 强调考虑心脏淋巴瘤在患有心脏不全症的猫身上的重要性.
主要方法:
- 对一只10岁的家养短发猫进行了尸检,该猫有FIV,糖尿病和心血管疾病的病史.
- 心脏组织的组织病理学评估.
- 免疫组织化学测定瘤细胞系.
主要成果:
- 在心脏中发现了一个大规模透的圆细胞瘤.
- 免疫组织化学证实了瘤是扩散的大B细胞淋巴瘤.
- 这只猫曾经患有慢性猫性隐形病毒感染.
结论:
- 这种病例呈现出心脏扩散大B细胞淋巴瘤的特殊表现.
- 慢性猫类隐形病毒感染可能在心脏淋巴瘤的发病和进展中起作用.
- 应将心脏淋巴瘤纳入患有充血性心力衰竭的猫的差异诊断.
相关概念视频
Cardiomyopathy II: Dilated Cardiomyopathy
1
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
1
Heart Failure III: Clinical Manifestations
3
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
3
Heart Failure IV: Classification and Diagnostic Evaluation
2
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
2
Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
Cardiomyopathy III: Hypertrophic Cardiomyopathy
1
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
1
Heart Failure I: Introduction
2
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
2


