系统性硬化和阳门功能障碍:利兹的经验
Nikhil Suresh1,2, Ranjitha Karanth1,2, Ramsah Cheah2
1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Journal of scleroderma and related disorders
|October 10, 2024
概括
系统性硬化症会导致内部关节缩,导致便失禁. 这项研究发现,与对照人群相比,系统性硬化症和便失禁患者的关节厚度和静止压力显著降低.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性硬化症 (SSc) 是一种影响多个器官的自身免疫性疾病,经常涉及胃肠道.
- 直肠功能障碍,特别是内部关节缩 (IAS) 缩,是SSc患者的常见并发症.
- 在SSc中便失禁 (FI) 通常归因于IAS缩.
研究的目的:
- 在SSc和FI患者中评估内部关节 (IAS).
- 为了比较SSc患者与FI和对照组之间的IAS特征.
- 调查SSc,IAS结构和FI症状之间的关系.
主要方法:
- 直肠测量和内超声波用于评估IAS.
- 17名SSc和FI患者与年龄和性别匹配的对照组进行了比较.
- 记录了患者的人口统计,临床表现 (泄漏,紧急情况) 和直肠感觉.
主要成果:
- 与对照组相比,全身性硬化症患者的IAS平均厚度明显较低 (p < 0.001).
- 在SSc患有FI的患者中观察到较低的基底缩压.
- 直肠的感觉被保留了,外部关节的厚度在各组之间没有差异.
结论:
- 内部关节缩是与全身性硬化症相关的便失禁的关键因素.
- 减少IAS厚度和静止压力有助于SSc中的被动便泄漏.
- 需要对SSc中的FI的自然史,风险因素和治疗方法进行进一步的研究.
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