人类介质干细胞及其衍生物的抗菌作用:系统性审查
Adeline Castro Ramos1, Markus Yovian Widjaja Lomanto2, Cat-Khanh Vuong3
1Graduate School of Comprehensive Human Science, Laboratory of Regenerative Medicine and Stem Cell Biology, University of Tsukuba, Tsukuba, Japan.
Frontiers in microbiology
|October 10, 2024
概括
介酶干细胞 (MSC) 显示出作为抗菌素耐药性 (AMR) 的替代治疗方法的希望. 研究表明MSC可以降低细菌负荷,骨髓衍生MSC特别有效.
科学领域:
- 生物医学科学 生物医学科学
- 干细胞生物学 干细胞生物学
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 是一个主要的全球健康威胁,由于缺乏新的抗生素.
- 介酶干细胞 (MSC) 具有免疫调节和直接的抗微生物特性.
- 研究MSC提供了潜在的替代治疗策略.
研究的目的:
- 对MSC及其成分的抗菌性质进行系统的文献审查.
- 评估MSCs在对抗细菌殖民化的有效性.
- 提供关于MSC抗菌潜力的现有研究结果的概述.
主要方法:
- 对PubMed,Embase和Web of Science数据库的系统文献审查.
- 分析了3,911篇选文章,其中31篇被选中.
- 与对照组相比,MSC处理后细菌减少百分比的量化.
主要成果:
- 大多数研究表明,使用MSC或其衍生品可以显著降低细菌负载.
- 来自骨髓的MSC显示出最高的疗效.
- 结果的异质性被观察到,可能是由于不同的MSC来源和研究设计 (体内/体外).
结论:
- 多重复合物表现出直接的抗微生物活性,减少细菌生长.
- 需要进一步的研究,以阐明影响MSC抗菌疗效的特定成分和因素.
- 多种微生物菌体是解决抗微生物药物耐药性的有希望的途径.
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