抗性是现实:乌克兰首次累积抗生素图的研究结果
Arkadii Vodianyk1, Oksana Holovnia2, Eugene Diomin1
1Service Delivery Department, WHO Country Office for Ukraine, Kyiv, Ukraine.
JAC-antimicrobial resistance
|October 10, 2024
概括
乌克兰 乌克兰 乌克兰 乌克兰
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 构成了全球重大健康挑战.
- 乌克兰以前缺乏累积抗生素图 (CuAbgms) 来追踪耐药性模式.
- 本研究解决了乌克兰对本地AMR数据的关键需求.
研究的目的:
- 在乌克兰开发和描述第一个累积抗生素图 (CuAbgm).
- 为指导抗微生物治疗和管理提供必要的数据.
- 支持感染控制措施,特别是在战争期间.
主要方法:
- 为Okhmatdyt国家专门儿童医院创建了一个CuAbgm.
- 数据使用WHONET软件进行管理.
- 抗微生物敏感性测试遵循EUCAST的指导方针,其开发以CLSI标准为指导.
主要成果:
- 在*Klebsiella pneumoniae*和*Pseudomonas aeruginosa*等格兰氏阴性细菌中观察到高耐药率,对包括美罗在内的关键抗生素具有很高的耐药性.
- *大肠杆菌 *与 *K.肺炎* 相比,对塞夫塔齐迪姆,塞夫特里亚和美罗的敏感性更高.
- 耐卡巴尼姆的 *K. pneumoniae* 和 *P. aeruginosa* 显示对塞夫塔齐迪姆/阿维巴克坦的敏感性有限.
结论:
- 乌克兰的第一个CuAbgm检测显示,在格拉姆阴性病原体中显著的AMR.
- 优先考虑CuAbgm开发对于乌克兰的抗菌药物管理和经验治疗至关重要.
- 这些数据对于管理复杂的感染至关重要,特别是在战时受伤的背景下.
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