黄金葡萄球菌 (Staphylococcus aureus) 溶于的模块素介于与上呼吸道共体细菌的物种间竞争
bioRxiv : the preprint server for biology
|October 10, 2024
概括
黄金葡萄球菌使用毒素来抑制共生细菌的聚合,促进慢性鼻炎 (CRS) 的失生症. 这种机制有助于S. aureus在CRS患者中主导上呼吸道 (URT) 微生物组.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 上呼吸道 (URT) 中的微生物失调与慢性鼻炎 (CRS) 的致病性有关.
- 黄金葡萄球菌是一种常见的URT病原体,在CRS中携带率更高,与更糟糕的疾病结果相关.
研究的目的:
- 研究S. aureus可能在URT中超越共生微生物的机制.
- 描述S. aureus中一种与CRS相关的分泌毒素如何抑制共体聚合和粘附.
主要方法:
- 使用Corynebacterium pseudodiphtheriticum作为一个模型开始性URT物种.
- 确定并测试了S. aureus δ-毒素 (Hld) 对C. pseudodiphtheriticum聚合的影响.
- 使用空气-液体接口模型评估重组δ-毒素对C. pseudodiphtheriticum粘附和聚合在人类鼻腔上皮细胞的影响.
主要成果:
- S. aureus δ-toxin (Hld) 被确定为一种分泌的蛋白质,在生物学相关的度下抑制C. pseudodiphtheriticum聚合.
- 重组δ毒素降低了C. pseudodiphtheriticum在人类鼻腔上皮细胞上的粘附和聚合.
结论:
- 黄金色 δ-毒素提供了一种新的机制来破坏URT中的共生微生物竞争者.
- 这种中介于毒素的对抗作用有助于S. aureus在CRS微生物群中占主导地位和微生物失调.
相关概念视频
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Gene Regulation in Microbial Communities: Quorum Sensing
3
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
3
Bacterial Phylum Actinobacteria
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Antimicrobial Proteins
942
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
942
Bacterial Signaling
31.6K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.6K


