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Updated: Jun 11, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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强效和选择性SETDB1共价负基调节器 降低细胞中的甲基转移酶活性

Mélanie Uguen, Devan J Shell, Madhushika Silva

    bioRxiv : the preprint server for biology
    |October 10, 2024
    PubMed
    概括

    研究人员开发了UNC10013,一种强大的共价接体,向SETDB1的三重图多域 (3TD). 这种选择性分子调节细胞中的SETDB1活性,为研究癌症和神经退行性疾病提供了一个新的工具.

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