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Updated: Jun 11, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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Published on: March 31, 2019

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与SIN3A结合THOC1复合体,以调节R环并促进质母细胞瘤的进展

Shreya Budhiraja, Shivani Baisiwala, Sia Cho

    bioRxiv : the preprint server for biology
    |October 10, 2024
    PubMed
    概括

    通过调节R循环,THO复合物1 (THOC1) 驱动着质母细胞瘤 (GBM) 的扩散. 抑制THOC1通过破坏端粒R循环平衡来降低GBM活力和瘤生长,提供了一个潜在的治疗策略.

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