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Updated: Jun 11, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

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用大规模突变扫描和深度学习预测和设计转录抑制器域

Raeline Valbuena, AkshatKumar Nigam, Josh Tycko

    bioRxiv : the preprint server for biology
    |October 10, 2024
    PubMed
    概括

    了解遗传变异如何影响转录抑制器域 (RDs) 是至关重要的. 这项研究绘制了变异活性图,确定了与疾病相关的突变,并开发了一个深度学习模型 (TENet) 来预测和设计调节性蛋白质功能.

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