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相关概念视频

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
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脂肪细胞的代谢状态调节了质细胞功能.

Mroj Alassaf1, Akhila Rajan1

  • 1Basic Sciences Division, Fred Hutch, Seattle, WA-98109. The USA.

bioRxiv : the preprint server for biology
|October 10, 2024
PubMed
概括

肥胖会破坏脂肪细胞-大脑轴,损害质细胞清除神经碎片的能力. 这项研究确定了一种新的脂蛋白信号通路,将代谢障碍与神经退行联系起来.

科学领域:

  • 神经科学是一个神经科学.
  • 代谢障碍 代谢障碍 代谢障碍
  • 细胞生物学 细胞生物学

背景情况:

  • 肥胖和2型糖尿病是神经退行性疾病的危险因素.
  • 脂肪细胞-大脑轴,涉及脂肪细胞的信号分子,对大脑功能至关重要,但其在神经退行过程中的作用尚不清楚.
  • 质细胞清除神经碎片,这是对大脑健康至关重要的过程.

研究的目的:

  • 研究脂肪细胞代谢如何影响大脑中的质细胞活动.
  • 确定将代谢障碍与质功能受损和神经退行症联系起来的分子机制.

主要方法:

  • 使用的成年 *Drosophila* (果) 模型.
  • 研究了长期肥胖性饮食对脂肪细胞代谢和质细胞灭菌的影响.
  • 采用基因操纵来改变脂肪细胞脂质和线粒体代谢.
  • 研究了 *Apolpp* (阿波蛋白B) 和脂蛋白受体1 (LpR1) 在质细胞化中的作用.

主要成果:

  • 肥胖性饮食增加了脂肪细胞脂肪酸氧化和生成.
  • 脂肪细胞中饮食诱导的代谢变化减少了细胞受体Draper在质细胞中的表达.
  • 脂肪细胞衍生*Apolpp*被确定为调节质细胞灭菌的关键信号.

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  • 脑细胞上的脂蛋白受体1 (LpR1) 对于清除神经元残渣至关重要.
  • 结论:

    • 脂肪细胞的新陈代谢通过脂蛋白信号传递显著影响质细胞功能.
    • 这一途径将代谢障碍,如肥胖,与神经碎片清除受损以及潜在的神经退行症联系起来.
    • 研究结果揭示了一种新的机制,将脂肪细胞-大脑轴连接到大脑健康和疾病.