使用基于临床的预测工具在2型糖尿病患者中识别与代谢功能障碍相关的脂肪性肝病
Juma Alkaabi1, Bachar Afandi2, Omar Alhaj2
1Internal Medicine Department, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Frontiers in medicine
|October 10, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在2型糖尿病患者中很常见. 像NFS和Fib-4这样的非侵入性得分显示了在初级保健中检测MASLD的可变准确性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 诊断成像 诊断成像 诊断成像
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是全球普遍存在的肝病.
- MASLD经常与2型糖尿病 (T2DM) 共同存在.
- 非侵入性纤维化评估工具对于MASLD管理至关重要.
研究的目的:
- 用哈马古奇超声波得分来确定T2DM患者的MASLD患病率.
- 为了评估NAFLD纤维化得分 (NFS) 和FIB-4指数在这个人群中对MASLD的诊断准确性.
主要方法:
- 在5年内对2型糖尿病患者进行肝超声波和实验室测试的回顾性图表审查.
- 查了6214个记录,其中153名患者符合纳入标准.
- 根据Hamaguchi分级标准对MASLD进行诊断.
主要成果:
- 在选择的T2DM患者中,45.1%的患者被诊断出MASLD.
- 在NAFLD纤维化评分 (NFS) 中,敏感度为79.7%,特异性为10.7%.
- 在MASLD检测中,FIB-4指数显示了30.4%的灵敏度和54.8%的特异性.
结论:
- 在T2DM患者中,MASLD的流行率很高.
- 在初级保健机构中,NFS和FIB-4为MASLD查提供了可变的实用性.
- 进一步的研究可能会完善这些非侵入性工具在T2DM患者中的应用.
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