肠道微生物群在前列腺炎症和良性前列腺增生中的作用及其治疗含义
Jie Chen1,2, Bo Chen1,2, Bin Lin3
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
Heliyon
|October 10, 2024
概括
肠道微生物群的失调有助于前列腺炎症和良性前列腺增生 (BPH). 减少的短链脂肪酸 (SCFA) 和受损的肠道屏障功能允许细菌转移,通过微生物相关分子模式 (MAMPs) 驱动炎症.
科学领域:
- 微生物组研究的研究.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群的生态平衡对宿主健康至关重要.
- 肠道微生物组的失调越来越多地与疾病有关,包括前列腺炎症.
- 了解这种联系对于开发新的治疗策略至关重要.
研究的目的:
- 审查肠道微生物群影响前列腺炎症和良性前列腺增生 (BPH) 的机制.
- 探索针对这些疾病的肠道微生物群的治疗含义.
主要方法:
- 在2023年4月之前对出版物的系统审查.
- 专注于肠道微生物群,前列腺炎症和BPH.
- 使用PICO框架制定的研究问题.
主要成果:
- 审查中包括了15篇文章.
- 涵盖了肠道微生物群和前列腺炎症/BPH之间的关系.
- 确定了详细的机制和潜在的治疗方法.
结论:
- 肠道微生物群的代谢物,如短链脂肪酸 (SCFA),对于肠道屏障完整性和免疫调节至关重要.
- 失生症降低了SCFA,破坏了肠道屏障,并促进了细菌转移.
- 转移的细菌和成分 (例如,脂多糖) 通过微生物相关分子模式 (MAMPs) 触发前列腺炎症.
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