CAE-ResVGG FusionNet:一个特征提取框架,集成卷积自编码器和转移学习,用于急性髓性白血病中不成熟的白细胞
Tusneem Elhassan1, Ahmed Hamza Osman2, Mohd Shafry Mohd Rahim3,4
1Cancer Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia.
Heliyon
|October 10, 2024
概括
一个新的AI框架,CAE-ResVGG FusionNet,通过分析不成熟的白细胞 (WBCs) 准确检测和分类急性髓性白血病 (AML). 这种自动化系统为手动诊断提供了一个更快,更可靠的替代方案,以改善患者的治疗结果.
科学领域:
- 血液学 血液学 血液学
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 急性髓性白血病 (AML) 诊断依赖于手动的外周血液涂抹分析,这是劳动密集的,容易出错的,并且受观察者之间的变化影响.
- 及时和准确的AML检测对于有效的治疗和改善患者预后至关重要.
- 开发自动诊断工具可以提高AML识别的效率和可靠性.
研究的目的:
- 开发和验证计算机辅助诊断 (CAD) 框架,CAE-ResVGG FusionNet,用于在急性髓性白血病 (AML) 中精确识别和亚型化不成熟白血细胞 (WBC).
- 将卷积自编码器 (CAE) 集成到 VGG19 和 ResNet50 架构中,以便对 WBC 进行强大的特征提取和分类.
- 建立一个计算效率高,高精度的AML诊断工具,超越现有的诊断方法.
主要方法:
- 开发了一个新的框架,CAE-ResVGG FusionNet,将CAE用于特征提取与VGG19和ResNet50用于分类.
- 工作流包括数据预处理与增强,使用CAE衍生嵌入和转移学习的特征提取,以及加权集团分类.
- 模型性能经过严格验证,使用准确度,精度,灵敏度和接收器操作特征曲线 (AUC) 下的面积.
主要成果:
- 该CAE-ResVGG FusionNet实现了99.9%的平均精度,91.7%的灵敏度和98.8%的精度.
- 该框架表现出异常的歧视能力,AUC为99.6%.
- 拟议的系统在准确性和可靠性方面明显优于以前的诊断方法.
结论:
- 该CAE-ResVGG FusionNet为急性髓性白血病 (AML) 诊断提供了一个高度准确和高效的自动化解决方案.
- 这种人工智能驱动的方法比传统的手工方法有了显著的进步,可能会提高诊断速度和一致性.
- 该框架的卓越性能凸显了其在AML检测和亚型化中的临床应用潜力.
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