随着时间的推移,急性护理药剂师处方和实验室订单的变化:CAPLET研究
Alexandra Charlton1, Cheryl Hill2, Deonne Dersch-Mills1
1, BScPharm, PharmD, ACPR, is with the Department of Pharmacy, Alberta Health Services, Calgary, Alberta.
The Canadian journal of hospital pharmacy
|October 10, 2024
概括
阿尔伯塔州急性护理机构的药剂师处方和实验室订单在2018年至2021年期间大幅增加. 虽然处方增加了67.5%,但实验室订单增加了5.5%,突出显示了实践范围的扩大.
科学领域:
- 药房实践 在药房实践中
- 医疗保健服务研究 医疗服务研究
- 临床药理学 临床药理学
背景情况:
- 加拿大阿尔伯塔省的药剂师拥有额外的处方授权 (APA) 和实践识别号码 (PRAC-ID) 来订购实验室测试.
- 阿尔伯塔省卫生服务部门在2018年之前要求药剂师使用APA;实验室订购自2009年以来已建立.
- 卡尔加里地区五个急性护理站点的计算机化提供者订单输入系统 (CPOE) 能够跟踪这些药剂师的活动.
研究的目的:
- 分析急性护理药剂师对药物处方和实验室测试订单的趋势.
- 将这些处方和订单活动在不同医院,场所和专科团队中进行比较.
- 评估医院药剂师扩大实践范围的演变.
主要方法:
- 对药剂师订单进行了后续描述性审查.
- 分析了来自五个急性护理场所的CPOE系统的数据,涵盖2018-2021年.
- 在研究期间检查了药物和实验室测试订购模式.
主要成果:
- 从2018年到2021年,药剂师处方率增加了67.5% (每次FTE1423到2383),实验室订单率增加了5.5% (每次FTE235到248).
- 在所有五家医院都观察到处方的显著增加,心脏病学,重症监护和心理健康领域的收益最大.
- 范科米辛是最常被处方的药物,而范科米辛的最低水平是最常见的实验室测试;口头药物订单从60.0%降至47.4%.
结论:
- 急性护理药剂师表现出他们扩大实践范围的利用率增加,特别是在处方方面.
- 药剂师的处方和实验室订单是互补的,经常协调相关药物和测试.
- 尽管取得了进展,但口头药物订单的比例很高,因此需要注意提高患者的安全性和优化CPOE系统的利用.
相关概念视频
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
96
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
96
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
47
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
47
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
50
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
50
Pharmacovigilance
783
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
783
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
96
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
96
Nonlinear Pharmacokinetics: Overview
295
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
Nonlinearity can arise due to the saturation of plasma protein-binding or...
295


