干细胞的类别:从生物学到工程
Shiv Shah1,2,3, Debolina Ghosh1, Takayoshi Otsuka1,2
1The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, 263 Farmington Avenue, Farmington, CT 06030-3711, USA.
Regenerative engineering and translational medicine
|October 10, 2024
概括
成人组织的自我修复能力有限. 本综述探讨了四种干细胞类型 - - 胚胎干细胞 (ESC),介质干细胞 (MSC),诱导多能干细胞 (iPSC) 和合成人工干细胞 (SASC) - - 用于肌肉骨再生工程.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 干细胞生物学 干细胞生物学
背景情况:
- 成人组织表现出较差的内在再生能力,限制了受伤或疾病后的自我修复能力.
- 干细胞,包括胚胎干细胞 (ESC),介质干细胞 (MSC) 和诱导多能干细胞 (iPSC),因其再生潜力而得到认可.
- 现有的干细胞类别在肌肉骨应用的临床翻译方面面临挑战.
研究的目的:
- 审查和比较四类干细胞:ESC,MSC,iPSC和新定义的合成人工干细胞 (SASC).
- 讨论这些干细胞类别在肌肉骨再生工程中的应用.
- 分析每个干细胞类别的优点,缺点和临床翻译影响.
主要方法:
- 采用了叙事审查方法.
- 使用PubMed和文献数据库进行的文献搜索.
- 选择相关的,高度引用的文章进行包含.
主要成果:
- 生物衍生 (ESC,MSC) 和工程 (iPSC,SASC) 干细胞类别的比较.
- 详细讨论干细胞在肌肉骨再生工程中的应用.
- 关于临床转换的每个干细胞类型的优缺点的总结.
结论:
- 每个干细胞类别在临床前和临床使用中都有独特的优点和缺点.
- 合成人工干细胞 (SASCs) 被提出作为一种新的,工程治疗方法.
- SASCs可能通过模仿内源干细胞的膜作用来增强再生,从而提供疾病修饰的潜力.
相关概念视频
01:17Stem Cell Culture
5.1K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.1K
00:58Embryonic Stem Cells
26.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
26.4K
01:27Source And Potency Of Stem Cells
4.7K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.7K
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
00:57Cellular Differentiation
2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
2.6K
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.4K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.4K