在 (前) 症状的荷兰型遗传性和偶发性脑粉样血管病变中认知
Rosemarie van Dort1, Kanishk Kaushik1, Ingeborg Rasing1
1Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 10, 2024
概括
大脑粉样性血管病变 (CAA) 导致认知能力下降,甚至在脑内出血 (ICH) 之前. 脑小血管疾病 (cSVD) 在MRI上增加的负担与CAA患者的处理速度减慢有关.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 认知科学 认知科学
背景情况:
- 大脑粉样血管病变 (CAA) 是老年人认知障碍的主要原因之一.
- 有限的数据存在于CAA的特定认知特征和早期认知功能,特别是关于与大脑小血管疾病 (cSVD) 负担的关联.
研究的目的:
- 调查荷兰型遗传CAA (D-CAA) 和零星CAA (sCAA) 患者的认知特征.
- 在CAA的脑内出血前 (ICH) 阶段评估认知功能.
- 确定基于MRI的cSVD负担与CAA中的认知功能之间的关系.
主要方法:
- 包括D-CAA突变载体 (有或没有ICH),sCAA患者和年龄匹配的对照.
- 标准化认知测试电池管理.
- 线性回归分析以将MRI-cSVD负担与认知表现相关联.
主要成果:
- 经历了ICH的D-CAA突变携带者表现出比对照组更差的全球认知和执行功能.
- 与D-CAA ICH+载体和对照组相比,sCAA患者在所有认知领域表现较差.
- 在较高的MRI-cSVD负载和较低的处理速度之间发现了显著的关联.
结论:
- CAA与多领域认知功能障碍有关,甚至在症状性ICH之前也可以检测到.
- 与对照组相比,没有症状的D-CAA突变携带者表现出认知缺陷.
- 在CAA中增加cSVD负担与处理速度降低相关,突显了早期认知评估的必要性.
关键词:
荷兰式遗传性大脑粉样血管病变大脑粉样性血管病变 - 大脑粉样性血管病变大脑小血管疾病负担大脑小血管疾病负担认知功能障碍 认知功能障碍遗传性脑粉样性血管病变 遗传性脑粉样性血管病变脑内出血 脑内出血磁共振成像技术的使用具有症状前的突变载体.更多相关视频
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