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早期癌症临床试验参与者的金融毒性
Sienna M Durbin1, Debra Lundquist2, Andrea Pelletier3
1Department of Medicine, Division of Hematology & Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA.
Cancer
|October 10, 2024
概括
在早期临床试验 (EP-CT) 中,超过三分之一的患者经历了财务毒性. 这种财务负担与生活质量下降以及对资源的担忧增加有关,这凸显了对支持的需求.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 患者报告的结果
背景情况:
- 早期临床试验 (EP-CT) 参与者的财务毒性尚不清楚.
- 这项研究旨在描述EP-CT参与者的金融毒性及其关联.
研究的目的:
- 描述EP-CT参与者中金融毒性的流行情况.
- 为了确定与金融毒性相关的患者特征.
- 探索金融毒性与患者报告结果 (PROs) 之间的关系,包括生活质量 (QOL) 和资源问题.
主要方法:
- 从2021年4月到2023年1月的EP-CT参与者的潜在招生.
- 在治疗开始时使用财务毒性综合评分评估财务毒性.
- 收集有关QOL,症状,应对机制和资源问题的数据.
主要成果:
- 在197名EP-CT参与者中,有34.0%的人报告了金融毒性.
- 财务毒性与年龄较小 (<65岁),失业,教育程度较低和收入较低 (<6万美元) 相关.
- 患有金融毒性的患者报告说,QOL显著降低,接受度降低,自我责备增加,对住房,账单,食物和就业更担心.
结论:
- 金融毒性是影响超过三分之一的EP-CT参与者的重要问题.
- 在金融毒性,质量生活,应对能力和资源问题之间发现了新的关联.
- 解决财务毒性对于支持早期临床试验中的患者至关重要.
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