调查患有或没有儿科严重抑郁症的青少年的甲状腺功能和状况
Ester Osuna1, Jeannine Baumgartner2, Andreas Walther3
1Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland.
The British journal of nutrition
|October 10, 2024
概括
在瑞士青少年中,有或没有严重抑郁症的营养充足. 然而,在患有儿科重度抑郁症 (pMDD) 的青少年,特别是女性中,观察到较低的自由甲状腺素 (FT4) 水平和较高的甲状腺素降低率.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 抑郁症与甲状腺功能障碍和下丘脑-垂体-甲状腺轴活动的改变有关.
- 对于保持健康的甲状腺功能至关重要.
研究的目的:
- 调查和甲状腺状况与瑞士青少年儿科主要抑郁症 (pMDD) 之间的关联.
- 探索这些关联中的潜在的性别差异和压力调解.
主要方法:
- 一个匹配的病例控制研究,涉及95名患有pMDD的青少年和95名健康对照.
- 评估抑郁症的严重程度,感知压力 (PSS),头发皮质醇,尿液度 (UIC),血清甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 的评估.
主要成果:
- 在病例和对照之间,尿液中度 (UIC) 中位数没有显著差异.
- 与对照人群相比,pMDD青少年的TSH和FT4水平中位数较低.
- 在女性病例 (21%) 与对照 (4%) 中,甲状腺血 (正常的TSH,低的FT4) 的患病率更高.
- 在某些情况下,PSS得分更高,头发皮质醇更低,但在调整后,这些关联失去了意义.
结论:
- 在研究群体中,营养充足.
- 较低的FT4度和较高的低甲状腺素血压患病率与青少年,特别是女性的pMDD有关.
- 甲状腺状况,特别是FT4,在青少年抑郁症的背景下值得考虑.
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