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多域蛋白-尿素相互作用:结合行为的差异导致单克隆抗体的不同不稳定趋势

Jiyoung Yang1,2, Oliver Burkert2, Boris Mizaikoff1

  • 1Institute for Analytical and Bioanalytical Chemistry, University of Ulm, Ulm D-89069, Germany.

The journal of physical chemistry. B
|October 10, 2024
PubMed
概括

尿素通过强烈结合来破坏单克隆抗体 (mAbs) 的稳定,在高温下增加聚合. 分子动力学模拟揭示了特定领域的相互作用,有助于药物配方开发.

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