血清肝酶和中风风险:用元分析和孟德尔随机化研究进行系统审查
Chun Li1,2, Long Gu3, Fu-Yi Shi4
1State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China.
像GGT和ALP这样的肝酶升高与中风风险增加有关. 这些发现表明肝酶是早期中风风险识别和个性化预防策略的潜在生物标志物.
科学领域:
- 心血管流行病学心血管流行病学
- 生物标志物发现发现
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明肝酶与中风风险之间存在联系,但研究结果不一致.
- 现有的研究缺乏对不同人群和中风类型中这种关联的全面评估.
研究的目的:
- 综合评估肝酶与中风风险之间的关系,使用元分析和门德尔随机化 (MR).
- 为了探索这一协会中的性别和中风亚型差异.
- 为了确定与肝酶相关的中风风险中性别差异的遗传基础.
主要方法:
- 根据PRISMA指南进行的17项前性研究的元分析.
- 使用大型GWAS总结数据进行双样双向单变量和多变量MR分析.
- 基因注释,基因组和组织丰富分析用于性别特异的遗传差异.
主要成果:
- 分析显示,随着血清马-氨基转移酶 (GGT) (RR 1.23) 和性酸酶 (ALP) (RR 1.3) 的升高,中风风险增加.
- 核磁共振分析证实了与中风相关的高GGT,氨基转移酶和酸氨基转移酶;较高的ALP显著增加了中风和缺血性中风风险.
- 亚组分析显示了性别和中风亚型的变化;遗传分析支持肝酶的性别特异性差异.
结论:
- 肝酶水平与中风风险有关,将其确定为早期风险分层的潜在生物标志物.
- 针对肝酶的性别特定干预措施可能提供新的中风预防策略.
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