儿童分化甲状腺癌的年龄分层和预后因素分析
Ophir Winder1, Liora Lazar2, Roy Hod1
1Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center and Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
The Laryngoscope
|October 10, 2024
概括
被诊断为差异化甲状腺癌 (DTC) 的年轻儿童表现出更具侵略性的疾病特征和较低的早期缓解率. 然而,儿童DTC患者的长期结果仍然是有利的.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 差异化甲状腺癌 (DTC) 在儿童中不常见.
- 诊断时的年龄和儿科DTC中的疾病攻击性之间的关系尚未完全理解.
- 确定预后因素对于定制治疗和改善结果至关重要.
研究的目的:
- 为了确定积极的儿科DTC的预后因素.
- 定义适合儿童DTC风险评估的年龄分层.
- 评估年龄对疾病攻击性和治疗结果的影响.
主要方法:
- 在1985年至2021年期间接受DTC治疗的儿科患者 (≤18岁) 的回顾性队列研究.
- 治疗后至少1.5年的随访时间.
- 美国甲状腺协会 (ATA) 风险分层,病原体特征和疾病按年龄进展的分析.
主要成果:
- 年轻的患者 (<11岁) 显示出更具侵略性的疾病特征,包括更高的ATA风险和转移性疾病.
- 11岁以下的儿童在治疗后1年有明显更高的疾病证据率 (66.7%vs25.4%).
- 8岁以下的患者有更频繁的双边疾病和甲状腺外延伸.
结论:
- 儿童DTC患者在11岁之前被诊断出患有更具侵略性的疾病和较低的早期缓解率.
- 尽管存在最初的挑战,但儿童DTC患者的长期结果通常是令人满意的.
- 诊断时的年龄是影响儿科DTC疾病行为的一个重要因素.
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