骨质疏松症患者体力活动与死亡率之间的关联:NHANESES的队列研究
概括
与普通人群相比,骨质疏松患者需要更高的体力活动量 (≥300分钟/周) 来降低死亡风险. 较高的活动水平与骨质疏松症患者的较低死亡率相关.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是指老年学的学科.
背景情况:
- 骨质疏松症是与死亡风险增加相关的重大公共卫生问题.
- 身体活动对骨质疏松症患者死亡率的影响尚未完全理解.
- 现有的研究往往不能根据骨质疏松症状况区分体育活动的影响.
研究的目的:
- 研究骨质疏松症患者体力活动量与全因和心血管死亡率之间的关系.
- 为了比较骨质疏松症和非骨质疏松症个体之间的身体活动和死亡率的剂量反应关系.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) 的数据,对5606名参与者进行了调查,其中716人患有骨质疏松症.
- 使用标准化问卷来评估身体活动,将参与者分为不活动,低活动 (<150分钟/周),中等活动 (150-299分钟/周) 和高活动 (≥300分钟/周).
- 采用多变量考克斯回归模型和受限立方线分析,调整混因子,以确定危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 骨质疏松症患者的死亡率高于非骨质疏松症患者.
- 身体活动与两组死亡率的降低有关,但只有高度活跃的 (≥300分钟/周) 骨质疏松症患者显示出所有原因和心血管死亡率的显著降低.
- 在骨质疏松症患者中观察到身体活动量和死亡率之间的线性剂量反应关系,与非骨质疏松症参与者的非线性关系形成鲜明对比.
结论:
- 骨质疏松症患者需要每周至少300分钟的体力活动,以实现显著的死亡率益处.
- 这些发现表明,骨质疏松症患者的死亡风险降低的身体活动值较高.
- 增加体力活动量表明,对于患有骨质疏松症的人来说,剂量取决于死亡风险的减少.
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