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Updated: Jun 10, 2025

Method of Studying Palatal Fusion using Static Organ Culture

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Published on: September 19, 2015

在五个阿拉伯国家,口唇裂和周围概念COVID-19感染

Heba Jafar Sabbagh¹, Mohammad Zeinalddin², Ola B Al-Batayneh^3,4

¹Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia. hsabbagh@kau.edu.sa.

Clinical oral investigations

|October 10, 2024

概括

在怀孕前和早期怀孕期间的母体COVID-19感染显著增加了带有或没有裂 palates (CL/P) 的严重裂唇的风险. 产前补充剂可以提供对CL/P严重性的保护作用.

科学领域:

医学研究医学研究
公共卫生公共卫生
遗传学遗传学是一个

背景情况:

影响带有或没有裂口口唇 (CL/P) 严重程度的因素尚不清楚,特别是在COVID-19流行病背景下.
疫情引入了重大的全球变化,影响了母亲的健康和怀孕结果.

研究的目的:

调查COVID-19感染,COVID-19的恐惧,以及婴儿中CL/P的严重程度之间的关联.
分析五个阿拉伯国家的这些协会.

主要方法:

一项涉及273名患有CL/P的婴儿及其母亲的横截面研究在五个阿拉伯国家的主要医院进行 (2020年11月至2023年4月).
婴儿的CL/P病例被表型分类,以评估严重程度 (例如,裂唇和口与裂唇,不完整与完整的延伸,单边与双边).
收集了关于母亲在孕期第一季度感染COVID-19和对COVID-19的恐惧的数据.

主要成果:

孕妇在怀孕前一个月和头三个月内感染COVID-19显著与严重CL/P的更高可能性有关 (调整几率比率[AOR]=2.707;P=0.002).
产前补充剂的使用显示出潜在的保护作用,降低了CL/P严重程度的几率 (AOR = 0.573;P = 0.065).

结论:

在怀孕初期和怀孕前的母体COVID-19感染与婴儿出现更严重的CL/P表型的几率增加了一倍多.
这些发现凸显了SARS-CoV-2感染在关键发育窗口中的潜在原性影响.

关键词:

在 COVID-19 疫情中,嘴唇裂口是一个问题.破裂的宫殿口.面部或脸部的裂.沙特阿拉伯沙特阿拉伯沙特阿拉伯严重程度严重程度

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