环境空气污染物对胎盘功能和妊娠结果的影响:分子洞察
Sunil Singh1, Isha Goel2, Smita Tripathi3
1Department of Biochemistry, All India Institute of Medical Sciences, Room 3020, New Delhi, 110029, India.
Environmental science and pollution research international
|October 10, 2024
概括
产前暴露于空气污染会损害怀孕,导致低出生体重和早产等不良结果. 污染物影响胎盘功能,可能导致婴儿的长期健康问题.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 发育儿科 发育儿科
背景情况:
- 空气污染是一个重大的全球健康问题,尤其影响像孕妇这样的弱势群体.
- 产前暴露于空气污染物与不良妊娠结果有关,包括胎儿生长减缓和早产.
研究的目的:
- 审查空气污染物,特别是颗粒物对怀孕的有害影响.
- 阐明空气污染物影响胎盘功能并导致不良结果的机制.
- 总结研究空气污染对怀孕和产后发育的影响的动物模型的发现.
主要方法:
- 文献综述综合了有关空气污染和怀孕结果的现有研究.
- 机械路径的分析,包括胎盘转移,氧化应激,炎症和表观遗传变化.
- 检查动物模型研究,以了解生物反应.
主要成果:
- 颗粒物可以穿过胎盘,破坏胎盘功能和平衡.
- 空气污染物与子宫前,妊娠高血压,氧化应激,炎症和胎盘表观遗传变化有关.
- 产前暴露与婴儿认知/运动功能下降以及自闭症谱和神经精神疾病风险增加有关.
结论:
- 空气污染通过各种生物途径对怀孕和胎儿发育构成重大风险.
- 了解这些机制对于制定减轻风险和保护母婴健康的策略至关重要.
- 需要有效的环境政策来减少全球空气污染相关疾病的负担,特别是在发展中国家.
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