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瘤微环境响应Zn(II) - 氨酸纳米异常剂用于向的声动疗法

Jiaxin Li¹, Zhitong Zhao¹, Yongchang Tian¹

¹Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.

ACS biomaterials science & engineering

|October 10, 2024

概括

通过向瘤和在酸性分解时释放声敏化剂TCPP来增强新型纳米听力学 (HA@Zn-TCPP) 的声动疗法 (SDT). 这种方法实现了显著的瘤抑制,为非侵入性癌症治疗提供了有希望的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

声动疗 (SDT) 是一个有前途的非侵入性瘤治疗方法.
传统的声敏化剂面临着诸如溶解性差,生物相容性和准等挑战.
改善SDT需要具有增强瘤积累和控制药物释放的新材料.

研究的目的:

开发用于增强SDT的新型(II) - 氨酸纳米异常剂 (HA@Zn-TCPP).
为了提高 sonosensitizers 的准能力和生物相容性.
为了在瘤微环境中实现对声敏剂的控制释放.

主要方法:

制造 (II) - 氨酸 (TCPP) 的金属有机框架.
用氨酸 (HA) 修改用于CD44受体向.
在体外和体内对HA@Zn-TCPP进行SDT疗效的评估.

主要成果:

HA@Zn-TCPP在CD44过度表达的瘤细胞中表现出特定的向和内部化.
酸性瘤微环境触发了HA@Zn-TCPP分解,释放了TCPP.
使用HA@Zn-TCPP的超声波激活SDT实现了82.1%的瘤抑制率.
控制的活性氧物种 (ROS) 生产将正常组织的损伤降至最低.

结论:

对于有针对性的SDT,HA@Zn-TCPP纳米激光剂是有效的.
氨酸修饰增强了瘤向和药物释放.
这一策略为非侵入性癌症治疗提供了潜在的进步.

关键词:

Zn(II)金属有机的框架.其他纳米奇观物质.声动力学疗法是一种声动力学疗法.瘤的微环境是响应性的.

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