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Updated: Jun 10, 2025

Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase
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核糖体框架转移选择性地调节了一个错误折叠的CFTR变体的组装,功能和药理学救援

Patrick J Carmody1, Francis J Roushar1, Austin Tedman2

  • 1Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401.

Proceedings of the National Academy of Sciences of the United States of America
|October 10, 2024
PubMed
概括

在囊性纤维化转膜导电调节器 (CFTR) 中发现的一种新发现的RNA结构导致核糖体框架转移,影响蛋白质折叠和功能. 这一发现为囊性纤维化 (CF) 治疗提供了新的治疗点.

关键词:
在CFTR中,CFTR是最重要的.膜蛋白的折叠 膜蛋白的折叠编程的核糖体框架转移.蛋白质稳定症是一种蛋白质稳定症.核糖体的核糖体是指核糖体中的核糖体.

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