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在美国的数字队列研究中,在整个生命周期中潜在的雄激素过剩的迹象
Amber T Wolf1, Zifan Wang1, Jukka-Pekka Onnela2
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
The Journal of clinical endocrinology and metabolism
|October 10, 2024
概括
雄激素过量 (AE) 的迹象在不同的人口和健康群体之间有很大差异. 了解这种异质性是开发更具包容性的AE症状的诊断方法的关键,如 hirsutism 和.
科学领域:
- 内分泌学 在内分泌学.
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
背景情况:
- 雄激素过量 (AE) 症状在一个人的一生中以不同的方式出现.
- 了解AE症状的患病率和变异对于准确的诊断和管理至关重要.
研究的目的:
- 评估潜在的雄激素过量症状的流行程度.
- 检查这些迹象在各种人口和健康特征之间有何差异.
主要方法:
- 利用了来自美国24435名参与者的数字队列 (2019年11月至2022年12月) 的数据.
- 评估了自我报告的症状,包括可能的发症,下巴毛发,头皮脱发以及中度至重度的.
主要成果:
- 患病率:可能的发症 (6.9%),下巴毛发 (12.6%),头皮脱发 (1.7%),中度至严重的 (31.8%).
- 和随着年龄的增长而减少,而下巴和头皮毛发增加.
- 在西班牙裔和南亚参与者以及BMI较高的参与者中, hirsutism的患病率更高.
- 在PCOS患者中,更常见;在使用荷尔蒙避孕药时,发和脱发不太常见.
结论:
- 潜在的雄激素过量的迹象表现出基于人口和健康因素的显著变化.
- 调查结果强调了对AE的包容性,人口层面的评估策略的需要.
- 结果提供了对不同人群中AE症状呈现差异的见解.
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