睡眠不规则和2型糖尿病的发生率:成年人的基于设备的前性研究
Jean-Philippe Chaput1,2, Raaj Kishore Biswas3,4, Matthew Ahmadi3,4
1Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Diabetes care
|October 10, 2024
概括
不规则的睡眠模式增加了2型糖尿病 (T2D) 的风险,即使睡眠时间足够长. 保持一致的睡眠时间表对于预防T2D和改善代谢健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 睡眠的规律性越来越被认为是关键的健康因素.
- 睡眠模式的干扰与各种代谢障碍有关.
- 2型糖尿病 (T2D) 构成了全球重大健康挑战.
研究的目的:
- 通过加速度计测量睡眠规律与T2D发病率之间的关联.
- 为了确定是否遵守睡眠持续时间指南可以减轻与睡眠不规则相关的T2D风险.
主要方法:
- 一项前性队列研究,利用英国生物库的数据,从73630名年龄在40-79岁的成年人中获取数据.
- 睡眠规律性使用睡眠规律性指数 (SRI) 来评估的睡眠规律性,该指数来源于7天加速计数据.
- 在8年的随访期间,通过自我报告和健康记录追踪T2D发病率.
主要成果:
- 不规则睡眠者 (SRI <71.6) 和中度不规则睡眠者 (SRI 71.6-87.3) 与正常睡眠者 (SRI >87.3) 相比,显示T2D风险明显更高.
- 对SRI的连续分析表明,睡眠规律降低和T2D发病率增加之间存在剂量反应关系.
- 满足睡眠时间建议并不能消除与不规则或中度不规则的睡眠模式相关的T2D风险增加.
结论:
- 中度至高水平的睡眠不规则与T2D风险存在不利关联.
- 这些发现强调了睡眠持续性 (睡前和起床时间) 的重要性,而不仅仅是睡眠时间对于T2D预防.
- 未来的干预措施应优先考虑改善睡眠规律性,以及睡眠持续时间和质量.
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
512
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
512
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Insulin: Dosing Regimen and Adverse Effects
152
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
152
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Pathophysiology of Diabetes
881
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
881


