现场笔记:Mopox集群是由Tecovirimat耐药麻疹病毒引起的 - 五个州,2023年10月至2024年2月
MMWR. Morbidity and mortality weekly report
|October 10, 2024
概括
已经出现了耐Tecovirimat的mpox病毒 (MPXV) 菌株,F13蛋白中的突变. 这份报告详细介绍了在没有先前进行tecovirimat治疗的个体中出现的第二组耐药MPXV感染.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 德科维里马特是mpox (麻疹病毒,MPXV) 的关键抗病毒药物.
- 病毒F13蛋白中的突变可以赋予tecovirimat耐药性.
- 自2022年以来,已经检测到耐药的MPXV菌株,通常在免疫功能低下的患者中.
研究的目的:
- 报告耐Tecovirimat的MPXV.的出现和传播情况.
- 为了描述第二个,独特的Tecovirimat耐药MPXV感染集群.
主要方法:
- 通过测序对MPXV进行遗传监测.
- 对公共病毒基因组数据库的监测.
- 案例调查和流行病学分析.
主要成果:
- 已经确定了MPXV F13突变赋予tecovirimat耐药性的突变.
- 在多个州中发现了第二个不相关的集群,由18个抗tecovirimat的MPXV病例组成.
- 这些感染发生在没有先前使用tecovirimat治疗史的人群中.
结论:
- 耐Tecovirimat的MPXV菌株正在流传,并且可以在人群中传播.
- 持续监测MPXV中的抗病毒耐药性至关重要.
- 了解耐药菌株的传播动态对于公共卫生应对至关重要.
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