在COVID-19中,血细胞指数与阿迪波涅克丁和莱普丁水平之间的相关性
Mia Manojlovic1, Branislava Ilincic2, Marko Bojovic3
1University of Novi Sad, Faculty of Medicine in Novi Sad, Novi Sad, Serbia; Clinic for Endocrinology, Diabetes and Metabolic Disorders, University Clinical Center of Vojvodina, Novi Sad, Serbia.
Biomolecules & biomedicine
|October 10, 2024
概括
脂肪组织激素,如勒,与COVID-19患者的血小板数量和大小变化有关. 这表明脂肪组织在疾病中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 脂肪组织 (AT) 是一个动态的内分泌器官,影响系统代谢.
- COVID-19与复杂的病理生理变化有关,包括内分泌功能潜在的改变.
- 在病毒感染中,阿迪波金和血液学参数,特别是血小板之间的相互作用仍然不完全理解.
研究的目的:
- 为了研究COVID-19患者的阿迪波金水平和血细胞指数之间的关系.
- 在急性病毒感染期间探索脂肪组织的内分泌功能.
- 专门研究SARS-CoV-2阳性个体中阿迪波金和血小板参数之间的关联.
主要方法:
- 连续76名SARS-CoV-2阳性患者的横截面分析.
- 从周围静脉血液中测量阿迪波金水平 (莱普丁,阿迪波涅丁) 和血细胞指数.
- 统计分析包括相关性 (皮尔森/斯皮尔曼) 和线性回归模型.
主要成果:
- 瘦素水平与身体质量指数 (BMI) 和体脂质量 (BFM) 有正相关.
- 阿迪波涅克丁水平与BMI呈负相关性.
- 丁水平与平均血小板体积 (MPV),血小板分布宽度 (PDW) 和血小板大细胞比率 (P-LCR) 有显著的正相关.
- 阿迪波涅克丁水平与血红素 (HCT) 有负相关性.
结论:
- 脂肪组织衍生的激素,特别是素,与COVID-19中血小板指数的改变有关.
- 这些发现凸显了脂肪组织内分泌功能在COVID-19病原和血小板激活中的潜在作用.
- 需要进一步的研究来阐明将阿迪波金与病毒感染中的血液学变化联系在一起的机制.
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