江唐圣豪配方通过影响肠道-微生物群-大脑轴来发挥其抗糖尿病作用
Ying Bai1, Yi Zhao2, Jialin Jin3
1Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Beijing, China.
概括
江唐圣豪配方 (JTSHF) 通过调节肠道微生物群和肠-大脑轴来改善2型糖尿病. 这种传统的中医药增强了葡萄糖和脂质代谢,并降低了糖尿病小鼠的体重.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肠-大脑轴研究研究
- 传统中国医药 传统中国医药
背景情况:
- 2型糖尿病涉及胰岛素抵抗和失效的分泌.
- 肠道-微生物群-大脑轴对葡萄糖和脂质新陈代谢产生重要影响.
研究的目的:
- 评估江唐圣豪公式 (JTSHF) 对2型糖尿病小鼠模型血糖控制的影响.
- 通过肠道微生物群-大脑轴探索JTSHF的机制.
主要方法:
- 建立了一种2型糖尿病小鼠模型,使用高脂肪饮食和链毒素.
- 用JTSHF或甲福林治疗小鼠11周,监测代谢参数.
- 分析了肠道微生物组成,短链脂肪酸和结肠和下丘脑中的基因表达.
主要成果:
- JTSHF显著改善了葡萄糖和脂质代谢,并减少了体重.
- JTSHF改变了肠道微生物组成,增加了短链脂肪酸,并调节了结肠GPR41/43表达.
- JTSHF影响了下丘脑的POMC,AgRP,NPY表达,并改变了血清GLP-1和ghrelin水平.
结论:
- 通过调节肠道微生物群和代谢物,影响肠-大脑和下丘脑养中心,JTSHF具有抗糖尿病作用.
- 这项研究强调了JTSHF在通过肠-大脑轴管理代谢疾病方面的潜力.
- JTSHF为传统中医在代谢调节中的作用提供了新的见解.
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