与子宫内膜异位症相关的非持久性内分泌干扰化学物质的混合物
Junjie Ao1, Wenting Zhu2, Wen Jiang3
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Ecotoxicology and environmental safety
|October 10, 2024
概括
暴露于非持久性内分泌干扰化学物质 (EDC),包括酸盐和双,与更高的子宫内膜异位症风险有关. 这项研究强调了潜在的公共卫生策略,以预防子宫内膜异位症.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 非持久性内分泌干扰化学物质 (EDC) 已被公认为具有生殖毒性.
- 虽然单次EDC暴露与子宫内膜异位症有关,但混合暴露的数据仍然有限.
- 子宫内膜异位症在全球影响着大量女性,需要对其病因因素进行研究.
研究的目的:
- 调查暴露于非持久性EDC (酸盐和双) 混合物和子宫内膜异位症风险之间的关联.
- 确定有助于子宫内膜异位症风险的特定EDC.
- 探索不同类型的EDC与子宫内膜异位症相关的潜在协同相互作用.
主要方法:
- 一项基于医院的病例控制研究,涉及中国的238例子宫内膜异位症病例和296例控制 (2014-2018).
- 在尿样中测量了17种非持久性EDC (酸盐和双).
- 统计建模使用后勤回归用于单个EDC分析和贝叶斯核机器回归 (BKMR),基于量子的g计算 (q-gcomp) 和主要组件分析 (PCA) 进行混合效应.
主要成果:
- 单个和混合模型都表明,酸盐和双与子宫内膜异位症的风险增加有关 (混合效应:调整后几率比 (aOR) =1.44,1.22-1.70).
- 双甲 (BPA) 和二2-乙基) 甲酸盐 (DEHP) 的代谢物被确定为这种关联的主要贡献者.
- 在双和酸盐之间观察到显著的协同相互作用.
结论:
- 不持久的EDC,特别是酸盐和双,与子宫内膜异位症的风险增加有关.
- 这些发现表明,对多种EDC的联合暴露可能比单个暴露带来更大的风险.
- 需要进一步的研究来阐明潜在的机制,对公共卫生干预和子宫内膜异位症预防策略的潜在影响.
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