禽病原性大肠杆菌 (APEC):当前的见解和未来的挑战
Saqib Nawaz1, Zhihao Wang2, Yan Zhang2
1Engineering Research Center for the Prevention and Control of Animal Original Zoonosis, Fujian Province, College of Life Science, Longyan University, Longyan, 364012, Fujian, China; Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, China.
Poultry science
|October 10, 2024
概括
禽类致病性大肠杆菌 (APEC) 是一种日益增长的食物传播威胁. 这篇综述详细介绍了APEC的细节.
科学领域:
- 兽医微生物学 兽医微生物学
- 食品安全 食品安全
- 动物传播疾病 动物传播疾病
背景情况:
- 禽类致病性大肠杆菌 (APEC) 在家禽中引起大肠杆菌病.
- 亚太经合组织越来越多地被认为是一种潜在的食物传播动物性传染病原体.
- 了解APEC的病原体对于公共卫生和动物福利至关重要.
研究的目的:
- 审查APEC的毒性因素和病原性.
- 评估亚太经合组织的动物感染潜力.
- 为APEC更新抗生素耐药性,疫苗研究和替代管理策略.
主要方法:
- 关于APEC研究的综合文献综述.
- 分析已确定的和新的毒性因素.
- 对流行病学数据和抗生素耐药性模式的评估.
主要成果:
- 亚太经合组织拥有多种多样的毒性因素,包括TCS,粘合素和毒素.
- 年轻的鸟类和压力因素增加了APEC的易感性和严重性.
- APEC O145是一种普遍的血清型;APEC表现出高水平的抗生素耐药性,包括对碳烯的耐药性.
结论:
- 亚太经合组织带来了相当大的动物感染风险,不应该被低估.
- 迫切需要一个广泛的APEC疫苗.
- 病毒抑制剂提供了一个有前途的替代策略来对抗APEC感染和耐药性.
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