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Updated: Jun 10, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

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核受体的PROTAC介导激活,而不是降解,揭示了复杂的连接体-受体相互作用网络

Andrew D Huber1, Wenwei Lin1, Shyaron Poudel1

  • 1Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1000, Memphis, TN 38105-3678, USA.

Structure (London, England : 1993)
|October 10, 2024
PubMed
概括

针对蛋白质溶解的嵌合体 (PROTACs) 连接器的小变化可以改变蛋白质降解活性. 结构研究揭示了链接器修改如何影响目标参与和E3结合酶招募,这对PROTAC有效性至关重要.

关键词:
这就是PROTAC.细胞染色体P450的使用.药物设计 药物设计代谢 代谢 代谢 代谢核受体是核受体的一个组成部分.怀孕前的X受体受体有针对性的蛋白质降解降解.

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