激素,压力和心脏病在LITE Plus中艾滋病毒感染的跨性别女性中
Tonia C Poteat1, Molly Ehrig2, Hedyeh Ahmadi3
1Division of Healthcare in Adult Populations, Duke University School of Nursing, Durham, North Carolina.
American journal of preventive medicine
|October 10, 2024
概括
压力显著影响艾滋病毒感染的跨性别女性 (TWHIV) 心血管疾病 (CVD) 风险. 虽然性别肯定激素治疗 (GAHT) 持续时间仅在高生理压力下增加心血管疾病风险,但其他因素也影响TWHIV心血管健康.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 心脏病学 心脏病学
背景情况:
- 心血管疾病 (CVD) 是跨性别女性和艾滋病毒感染者的主要健康问题.
- 外源性雌激素和心理社会压力因素是已知的心血管疾病风险因素.
- 对艾滋病毒感染的跨性别女性 (TWHIV) 压力和心血管疾病风险的生物标志物研究是有限的.
研究的目的:
- 调查压力在性别肯定激素治疗 (GAHT) 持续时间和TWHIV患者心血管疾病风险之间的关系中的缓和作用.
- 分析生理压力生物标志物与TWHIV中心血管疾病风险评分之间的关联.
主要方法:
- 对108名黑人和拉丁裔TWHIV的横截面分析.
- 通过对社会人口统计,病史和感知压力的调查收集的数据.
- 使用14个全静态负载指数 (ALI) 和皮质醇水平的生物标志物来评估生理压力.
- 使用2018年ACC/AHA聚合队列方程估计的10年心血管疾病风险.
主要成果:
- 在双变量分析中,性别确认激素治疗 (GAHT) 持续时间与心血管疾病风险有关.
- 在多变量模型中,只有年龄和全静态负载指数 (ALI) 仍然与心血管疾病风险有显著关联.
- 在压力测量和GAHT持续时间之间没有发现对心血管疾病风险的显著相互作用.
- 长时间的GAHT增加了心血管疾病风险得分,主要是在ALI最高的个体中.
结论:
- 由ALI指出的生理压力,在TWHIV中对心血管疾病风险起着重要作用.
- 需要进一步的研究来探索影响跨性别女性心血管疾病健康的非GAHT因素.
- 了解压力的影响对于减轻这种人群中心血管疾病风险至关重要.
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