黑色素缩激素促进通过侧面隔膜进行食
Mikayla A Payant1, Anjali Shankhatheertha1, Melissa J Chee1
1Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Progress in neuro-psychopharmacology & biological psychiatry
|October 10, 2024
概括
黑色素缩激素 (MCH) 通过作用于小鼠的侧隔膜 (LS) 来促进食. 这种效应取决于上下文,在熟悉的环境中发生,而不是新鲜的环境,并且被MCHR1对抗剂阻断.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经内分泌学神经内分泌学
背景情况:
- 养行为受到焦虑和恐惧的调节,需要对调节这些状态的神经系统进行研究.
- 黑色素缩激素 (MCH) 是来自横向下丘脑和不确定的区域的神经,促进食和焦虑.
- 侧隔膜 (LS) 参与促进食和抑制焦虑,从MCH神经元接收密集的投射.
研究的目的:
- 调查侧隔膜 (LS) 是否是MCH介导养的关键部位.
- 为了确定MCH是否通过LS中的MCH受体1 (MCHR1) 激活促进食.
- 在雄性和雌性小鼠中探索MCH诱导的食的上下文依赖.
主要方法:
- 在雄性和雌性小鼠的LS中双边输注MCH.
- 与MCH.同时使用MCHR1抗剂 (TC-MCH 7c) 与MCH.同时使用.
- 评估养行为在家庭和新的焦虑性环境.
主要成果:
- 在小鼠中,MCH输入LS显著增加了标准和可口饮食的食物消耗.
- 在LS中,MCH的促进养效应被MCHR1抗剂阻断.
- 在家庭子中观察到MCH诱导的食,但在新的焦虑性环境中取消了,而没有诱导类似焦虑的行为.
结论:
- 侧隔膜 (LS) 被确定为一种新的大脑区域,可以调解MCH的氧化作用.
- MCH以一种取决于环境的方式促进食,主要是在熟悉的环境中.
- 这些发现强调了LS在调节受MCH和环境环境影响的养行为中的作用.
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