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美国人口中PNPLA3 rs738409,环境因素和与肝脏有关的死亡率

Eduardo Vilar-Gomez¹, Samer Gawrieh¹, Raj Vuppalanchi¹

¹Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.

Journal of hepatology

|October 10, 2024

概括

PNPLA3基因变体增加了与肝脏相关的死亡风险,但咖啡和单不和脂肪等健康因素可以减轻这一点. 生活方式的选择显著改变了对肝病的遗传倾向.

科学领域:

遗传学和肝病学研究
营养流行病学营养流行病学
环境健康环境健康

背景情况:

PNPLA3 rs738409 C>G多态,环境因素和与肝脏相关的死亡风险之间的相互作用尚未得到充分理解.
研究这些相互作用对于理解肝病病因和预防至关重要.

研究的目的:

检查PNPLA3基因型,饮食模式,酒精摄入,吸烟和BMI与肝脏相关死亡的独立和联合关联.
确定环境因素如何改变PNPLA3.0所带来的遗传风险.

主要方法:

分析了来自NHANES III (1991-1994) 的4361名成年人,这些成年人与国家死亡指数联系在一起,直到2019年.
竞争的风险回归模型被用来评估PNPLA3,饮食,酒精,吸烟,BMI和肝脏相关死亡之间的关联.
评估PNPLA3与环境因素对肝脏相关死亡风险的相互作用影响.

主要成果:

PNPLA3 G-基因组与肝脏相关死亡的增加显著相关 (adj.sHR 2.9).
轻量饮酒,高胆固醇摄入量,吸烟和更高的BMI也增加了风险,而咖啡和单不和脂肪摄入量显示出保护作用.
相互作用表明,轻度酒精摄入,高胆固醇,吸烟和肥胖增加了G基因基因的风险,但咖啡和单不和脂肪摄入减弱了这种风险.

结论:

PNPLA3基因型显著影响与肝脏相关的死亡风险.
环境和人类学因素大大改变了与PNPLA3.3相关的遗传风险.
改变生活方式,包括健康饮食和减少饮酒/吸烟,可以减轻肝脏疾病的风险,即使在遗传敏感的个体.

关键词:

在 PNPLA3 rs738409 酒精酒精酒精酒精酒精酒精酒精酒精咖啡咖啡咖啡咖啡咖啡饮食饮食饮食饮食与肝脏相关的死亡率肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖吸烟是为了吸烟.

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