了解景观和促进使用指南的真实世界研究:一个范围审查
Yana Qi1, Kai Zhao2, Ningsu Chen2
1Center of Gerontology and Geriatrics, Chinese Evidence-Based Medicine Center and Cochrane China, West China Hospital, Sichuan University, Chengdu 610041, China; NMPA Key Laboratory for Real World Data Research and Evaluation in Hainan, Chengdu 610041, China; Sichuan Center of Technology Innovation for Real World Data, Chengdu 610041, China.
Journal of clinical epidemiology
|October 10, 2024
概括
本范围审查分析了1990年至2023年期间出版的61份真实世界研究 (RWS) 指南. 指南的目的和内容各不相同,强调需要改进开发方法和对特定研究目标进行仔细的研究人员评估.
科学领域:
- 卫生科学 卫生科学 卫生科学
- 医学研究方法学 医学研究方法学
背景情况:
- 现实世界研究 (RWS) 在医疗保健研究中越来越重要.
- 现有指南进行RWS缺乏标准化,并有很大的差异.
- 需要对当前的RWS指南进行全面的概述,以告知最佳实践.
研究的目的:
- 系统地识别和总结现有的现实研究指南 (RWS).
- 分析RWS指南的特性,内容和开发方法.
- 提供有关RWS指导当前情景的见解.
主要方法:
- 采用了一个范围审查方法,利用系统和雪球搜索.
- 搜索的数据库包括PubMed,科学网,CNKI,万芳和其他9个官方网站.
- 1990年1月1日至2023年12月31日期间出版的指南被选,由两个独立审查员提取数据.
主要成果:
- 确定了61个RWS指南,其中很大一部分是在2016年后出版的,并通过国际合作开发的.
- 大多数指南都是方法论性的,重点是观察性或干预性研究,涵盖了设计,进行,分析和报告等方面.
- 一小部分指南使用了基于证据和基于共识的开发方法.
结论:
- 现有的RWS指南在目的,格式和内容方面表现出相当多的异质性,通常是针对特定背景量身定制的.
- 在制定RWS指南时,需要改进方法.
- 研究人员必须仔细评估指南的范围,分类和适用性,以与他们的研究目标保持一致.
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