一个系统的研究Pseudobulbus Cremastrae seu Pleiones:特征,起源,化学成分和毒理学
Conghui Zhou1, Yuwei Jia1, Qi Zhang2
1College of Pharmaceutical Science, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou, 310014, China.
Journal of ethnopharmacology
|October 10, 2024
概括
评估了Pseudobulbus Cremastrae seu Pleiones (PCSP) 的真实性和安全性. Cremastra appendiculate (CA) 和Oreorchis patens (OPL) 是真实的,CA的毒性较低,更适合临床使用.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 传统中国医药 传统中国医药
- 化学分类学 化学分类学
背景情况:
- 伪obulbus Cremastrae seu Pleiones (PCSP) 是一种多来源的传统中医药 (TCM),具有可变的化学特征和毒性.
- 确保PCSP的真实性和安全性对于其临床应用至关重要.
研究的目的:
- 评估来自不同植物来源的商用PCSP的真实性和安全性.
- 为了准确识别,识别有区别的化学标记.
- 评估各种PCSP来源的毒理特征.
主要方法:
- 用了形态学,显微镜和HPLC分析来确定真实性.
- 具有分子网络的UPLC-Q-TOF-MS/MS用于化学分析.
- 在斑马鱼模型中进行了急性和肠道毒性评估.
主要成果:
- 根据形态和化学特征区分了四种不同的PCSP来源.
- 科尔奇辛和米利塔林被确定为区分PCSP来源的关键标志物.
- 鉴定出Cremastra appendiculate (CA) 和Oreorchis patens (OPL) 是真正的PCSP,与OPL相比,CA的急性和肠毒性较低.
结论:
- 通过形态,化学和毒理学评估的组合,可以可靠地确定PCSP的真实性.
- CA和OPL是真正的PCSP来源.
- CA 显示出优越的安全性,使其更适合临床应用.
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