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Updated: Jun 10, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

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开发一个TBXT-EGFP iPS细胞模型,用于选典型环境污染物的早期发育毒性

Yanyi Zhao1, Miaomiao Zhao2, Qingyuan Li1

  • 1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|October 10, 2024
PubMed
概括

新的干细胞模型改善了环境毒理学查. 研究人员确定了四种污染物 (TBBPA-BDBPE,TBBPA-BHEE,DG,AO2246),这些污染物可能会破坏TBXT基因表达,可能导致早期人类胚胎的发育异常.

关键词:
发展性毒性 发展性毒性环境污染物环境污染物干细胞的毒理学TBXT-EGFP诱导的多能干细胞 (iPS) 细胞.

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相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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