类似葡萄糖-1受体激动剂显著影响肠道准备结肠镜检查的质量
Naim Abu-Freha1,2,3, Avraham Yitzhak4, Haim Shirin5
1Gastroenterology Institute, Assuta Medical Center, Beer-Sheva, Israel.
类似葡萄糖-1受体激动剂 (GLP-1RAs) 与糖尿病患者和非糖尿病患者的结肠镜检查不充分的肠道准备率较高有关. 需要特别注意GLP-1RA患者,以确保充分准备结肠镜检查.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 内镜检查是指内镜检查.
背景情况:
- 已知类似葡萄糖-1受体激动剂 (GLP-1RAs) 可以减缓胃肠道运动.
- 关于GLP-1RAs对结肠镜检查准备剂适度的影响的数据有限.
研究的目的:
- 调查GLP-1RA使用与肠道不充分准备 (IBP) 结肠镜检查之间的关联.
- 确定GLP-1RA的使用是否是IBP的独立风险因素.
主要方法:
- 一个多中心的回顾性研究,将GLP-1RA用户与匹配的对照进行比较.
- 倾向性得分匹配用于控制年龄,性别,糖尿病,肥胖和并发症.
- 肠道准备不足被定义为在Aronchik或波士顿肠道准备等级上准备得分差.
主要成果:
- 使用GLP-1RAs的患者与对照组相比,IBP (10%) 的发生率明显高 (4%).
- GLP-1RA使用是IBP (OR2.7,P<0.001) 的独立风险因素,糖尿病也是 (OR1.4,P<0.001).
- 与相应的对照组相比,在接受GLP-1RA治疗的糖尿病患者和非糖尿病患者中观察到更高的IBP率.
结论:
- 使用GLP-1RA与肠道不充分准备结肠镜检查的风险增加有关.
- 对于接受结肠镜检查的GLP-1RAs的糖尿病患者和非糖尿病患者,需要量身定制的建议和更多的关注.
- 进一步的研究可能会探索在这种患者群体中优化肠道准备的具体策略.
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