肠道微生物组在代谢功能障碍相关的脂肪性肝病中的作用
Salim Maher1,2, Jayashi Rajapakse2, Emad El-Omar1,2
1Department of Gastroenterology and Hepatology, St George Hospital, Sydney, Australia.
Seminars in liver disease
|October 10, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在全球范围内正在增加,治疗方法有限. 针对肠道微生物组为MASLD提供了一个有前途的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD),以前是非酒精性脂肪性肝病,显示全球患病率正在上升.
- 目前对MASLD的治疗选择有限,需要新的治疗策略.
- 人们越来越认识到肠道微生物组在MASLD病变发生过程中的重要作用.
研究的目的:
- 审查肠道微生物组结构/功能和MASLD发展之间的复杂关系.
- 评估肠道微生物群签名的诊断潜力,以进行非侵入性MASLD严重性评估.
- 检查针对MASLD肠道微生物群-肝脏轴的现有和新型疗法.
主要方法:
- 关于研究肠道微生物组在MASLD中的综合文献评论.
- 对用于MASLD诊断和分期的基于微生物组的生物标志物的研究分析.
- 综合有关治疗干预措施的数据,调节肠道微生物组,以促进肝脏健康.
主要成果:
- 在MASLD患者中,肠道微生物组的组成和代谢活动发生了显著的改变.
- 基于微生物组的签名显示出潜在的非侵入性工具来识别MASLD及其严重程度.
- 准肠道微生物群-肝脏轴为MASLD提供了有前途的治疗途径.
结论:
- 肠道微生物组在MASLD的发展和进展中起着至关重要的作用.
- 肠道微生物组分析为MASLD诊断和严重性评估提供了一个有希望的非侵入性方法.
- 专注于肠道微生物群-肝脏轴的治疗策略对MASLD管理具有重大潜力.
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